Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that functions as an endogenous modulator of inflammation and pain. It exerts its effects through various mechanisms, including the activation of cannabinoid receptors and the inhibition of mast cell activation and pro-inflammatory cytokine release. PEA has demonstrated therapeutic potential in alleviating chronic pain conditions, such as neuropathic pain and inflammatory disorders, by reducing neuroinflammation and sensitization of pain pathways. Additionally, PEA has shown promise in supporting immune function, neuroprotection, and cellular homeostasis. As a dietary supplement, PEA is well-tolerated with minimal side effects, making it a promising option for individuals seeking natural alternatives for pain management and inflammatory relief.