Betaine anhydrous, scientifically known as trimethylglycine (TMG), is a naturally occurring compound derived from sugar beets. Its chemical structure consists of a trimethylammonium cation connected to a glycine, making it a versatile molecule with diverse biological functions. As a methyl donor, betaine anhydrous participates in crucial methylation processes within the body, aiding in the conversion of homocysteine to methionine and regulating homocysteine levels in the bloodstream. Moreover, betaine serves as an osmolyte, supporting cellular hydration and maintaining cell volume and integrity, particularly under conditions of osmotic stress. Beyond its roles in metabolism and cellular function, betaine anhydrous has garnered attention for its potential health benefits, including promoting heart health by reducing cardiovascular risk markers, supporting liver function by aiding in fat metabolism, and enhancing exercise performance by boosting strength and power output. Found naturally in foods like spinach, beets, quinoa, and whole grains, betaine anhydrous is also available as a dietary supplement, commonly taken in capsule or powder form. While generally regarded as safe, it’s important to use betaine anhydrous responsibly and consult with a healthcare professional, especially if considering supplementation for specific health goals or medical conditions.